Green tea consumption improves the therapeutic efficacy of deferoxamine on iron overload in patients with β-thalassemia major: a randomized clinical study

نویسندگان

  • Mahdieh Sadat Badiee
  • Hossein Nili-Ahmadabadi
  • Hamed Zeinvand-Lorestani
  • Amir Nili-Ahmadabadi
چکیده

Green tea (Camellia sinensis) is an important medicinal plants due to its potent antioxidant effects and metal chelating properties. This study was designed to explore the effects of green tea (GT) against iron overload in β-thalassemia major (TM) patients who were under regular chelation therapy with deferoxamine (DFO). Based on the standard method, 14 TM patients were, randomly, selected and their blood samples were collected immediately before and one month after GT administration (12 gr/day). Then, the blood levels of iron, ferritin, total iron-binding capacity (TIBC), lipid peroxidation (LPO), and hematological profile were determined. A significant decrease in the levels of iron (p<0.001), ferritin (p<0.01), LPO (p<0.001) and white blood cells (p<0.05) and a remarkable increase in TIBC levels (p<0.001) were noticed in the blood samples of TM patients thirty days after GT therapy while no significant changes were observed in the other hematological parameters. GT could be used as a supplement to DFO therapy in TM patients.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Sequential Deferoxamine - Deferasirox in Treatment of Major Thalassemia with Iron Overload

Abstract Background Iron overload is a major problem in patients with major thalassemia. An effective and safe iron chelator protocol with high compliance rate plays an important role in treatment of these patients. This study was done to assess the efficacy and safety of the sequential deferoxamine and deferasirox protocol in major thalassemia patients in Khuzestan province, Iran. Material ...

متن کامل

Effect of Combined versus Monotherapy with Deferoxamine and Deferiprone in Iron Overloaded Thalassemia Patients: a Randomized Clinical Trial

Background: Patients with transfusional iron overload have depended on iron chelation therapy and improving chelation regimens have been of the highest priority. The aim of this study was to compare effect of combined versus monotherapy with Deferoxamine (DFO) and Deferiprone (DFP) in iron overloaded beta thalassemia (BT) major patients Materials and Methods We studied 36 BT major patients (mea...

متن کامل

EVALUATION OF PULMONARY IRON OVER LOAD IN PATIENTS WITH Β-THALASSEMIA MAJOR USING SPIROMETRY

Background & Aims: Spirometry changes in thalassemic patients can be obstructive or restrictive and pulmonary dysfunction depends on age and body iron overload. In this study the effectiveness of lung spirometry in detecting iron overload in patients with β-thalassemia was investigated. Materials & Methods: This cross-sectional (descriptive-analytic) study investigated the spirometry test resu...

متن کامل

Comparison of iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and deferiprone on liver and cardiac T2* MRI in thalassemia maior

Background: Cardiac complications due to iron overload are the most common cause of death in patients with thalassemia major. The aim of this study was to compare iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and deferiprone on cardiac and liver iron load measured by T2* MRI. Methods: In this study, 108 patients with thalassemia major aged over 10 years...

متن کامل

Efficacy of Deferasirox (Exjade®) versus Osveral® in Treatment of Iron Overload in Patients with Beta- thalassemia Major in Iran; A Non-randomized Controlled Trial

Background: Iron chelators are an important part of management of patients with thalassemia. It is prudent to compare efficacy of different iron chelators in treatment of iron overload in these patients who receive regular blood transfusion. We aimed to compare the efficacy and safety of available oral iron chelator; Deferasirox (Exjade&reg;) with Deferasirox (Osveral&reg;) in reducing iron ove...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015