Green tea consumption improves the therapeutic efficacy of deferoxamine on iron overload in patients with β-thalassemia major: a randomized clinical study
نویسندگان
چکیده
Green tea (Camellia sinensis) is an important medicinal plants due to its potent antioxidant effects and metal chelating properties. This study was designed to explore the effects of green tea (GT) against iron overload in β-thalassemia major (TM) patients who were under regular chelation therapy with deferoxamine (DFO). Based on the standard method, 14 TM patients were, randomly, selected and their blood samples were collected immediately before and one month after GT administration (12 gr/day). Then, the blood levels of iron, ferritin, total iron-binding capacity (TIBC), lipid peroxidation (LPO), and hematological profile were determined. A significant decrease in the levels of iron (p<0.001), ferritin (p<0.01), LPO (p<0.001) and white blood cells (p<0.05) and a remarkable increase in TIBC levels (p<0.001) were noticed in the blood samples of TM patients thirty days after GT therapy while no significant changes were observed in the other hematological parameters. GT could be used as a supplement to DFO therapy in TM patients.
منابع مشابه
Sequential Deferoxamine - Deferasirox in Treatment of Major Thalassemia with Iron Overload
Abstract Background Iron overload is a major problem in patients with major thalassemia. An effective and safe iron chelator protocol with high compliance rate plays an important role in treatment of these patients. This study was done to assess the efficacy and safety of the sequential deferoxamine and deferasirox protocol in major thalassemia patients in Khuzestan province, Iran. Material ...
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